Towards a Framework for Better Understanding of Quiescent Cancer Cells
Open Access
- 5 March 2021
- Vol. 10 (3), 562
- https://doi.org/10.3390/cells10030562
Abstract
Quiescent cancer cells (QCCs) are cancer cells that are reversibly suspended in G0 phase with the ability to re-enter the cell cycle and initiate tumor growth, and, ultimately, cancer recurrence and metastasis. QCCs are also therapeutically challenging due to their resistance to most conventional cancer treatments that selectively act on proliferating cells. Considering the significant impact of QCCs on cancer progression and treatment, better understanding of appropriate experimental models, and the evaluation of QCCs are key questions in the field that have direct influence on potential pharmacological interventions. Here, this review focuses on existing and emerging preclinical models and detection methods for QCCs and discusses their respective features and scope for application. By providing a framework for selecting appropriate experimental models and investigative methods, the identification of the key players that regulate the survival and activation of QCCs and the development of more effective QCC-targeting therapeutic agents may mitigate the consequences of QCCs.Funding Information
- National Natural Science Foundation of China (81803571, 81973438)
- NSFC-Joint Foundation of Yunnan Province (U1902213, 2020B1111110003)
This publication has 82 references indexed in Scilit:
- Single-cell RNA-Seq of follicular lymphoma reveals malignant B-cell types and coexpression of T-cell immune checkpointsBlood, 2019
- A facile in vitro platform to study cancer cell dormancy under hypoxic microenvironments using CoCl2Journal of Biological Engineering, 2018
- Autophagy promotes the survival of dormant breast cancer cells and metastatic tumour recurrenceNature Communications, 2018
- Molecular Regulation of Cellular Quiescence: A Perspective from Adult Stem Cells and Its NichesPublished by Springer Science and Business Media LLC ,2017
- Tumor-reactive immune cells protect against metastatic tumor and induce immunoediting of indolent but not quiescent tumor cellsJournal of Leukocyte Biology, 2016
- The perivascular niche regulates breast tumour dormancyNature, 2013
- Gap Junction–Mediated Import of MicroRNA from Bone Marrow Stromal Cells Can Elicit Cell Cycle Quiescence in Breast Cancer CellsCancer Research, 2011
- Characterization and functional analysis of a slow cycling stem cell-like subpopulation in pancreas adenocarcinomaClinical & Experimental Metastasis, 2009
- A New Description of Cellular QuiescencePLoS Biology, 2006
- Chapter 27 Differential Staining of DNA and RNA in Intact Cells and Isolated Cell Nuclei with Acridine OrangeMethods in Cell Biology, 1990