Polyacrylonitrile-based carbon nanofibers as a matrix for laser desorption/ionization time-of-flight mass spectrometric analysis of small molecules under both positive and negative ionization modes
- 6 January 2021
- journal article
- research article
- Published by Springer Science and Business Media LLC in Analytical and Bioanalytical Chemistry
- Vol. 413 (4), 1193-1202
- https://doi.org/10.1007/s00216-020-03083-9
Abstract
Carbon fiber (CNF), prepared by carbonization of electrospun polyacrylonitrile (PAN) fibers, is systematically investigated as a mediator to replace conventional organic matrices for matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-MS). CNF exhibits a high salt tolerance, sensitivity, and resolution for organic matrix-free laser desorption/ionization time-of-flight mass spectrometry (LDI-MS) analysis of various analytes under both positive and negative ionization modes. Especially, saccharides, a neutral molecule having low negative ionization efficiency, are successfully detected with CNF. Taken together, this study clearly demonstrates CNF is a promising material to develop an efficient and universal platform for LDI-MS analysis regardless of preferential ionization modes of analytes. Graphical abstractKeywords
Funding Information
- the Ministry of Trade, Industry & Energy (R0005237)
- the Carbon Cluster Development Program (10083586)
- the Korea Research Council for Industrial Science & Technology (G02054)
- the National Research Foundation of Korea (2020R1F1A1070831)
- Korea Institute of Science and Technology (2Z06250)
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