Long wavelength single photon like driven photolysis via triplet triplet annihilation
Open Access
- 5 January 2021
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature Communications
- Vol. 12 (1), 1-10
- https://doi.org/10.1038/s41467-020-20326-6
Abstract
Photolysis has enabled the occurrence of numerous discoveries in chemistry, drug discovery and biology. However, there is a dearth of efficient long wavelength light mediated photolysis. Here, we report general and efficient long wavelength single photon method for a wide array of photolytic molecules via triplet-triplet annihilation photolysis. This method is versatile and “LEGO”-like. The light partners (the photosensitizers and the photolytic molecules) can be energetically matched to adapt to an extensive range of electromagnetic spectrum wavelengths and the diversified chemical structures of photoremovable protecting groups, photolabile linkages, as well as a broad array of targeted molecules. Compared to the existing photolysis methods, our strategy of triplet-triplet annihilation photolysis not only exhibits superior reaction yields, but also resolves the photodamage problem, regardless of whether they are single photon or multiple photon associated. Furthermore, the biological promise of this “LEGO” system was illustrated via developing ambient air-stable nanoparticles capable of triplet-triplet annihilation photolysis.Keywords
This publication has 35 references indexed in Scilit:
- Discovery of small molecule cancer drugs: Successes, challenges and opportunitiesMolecular Oncology, 2012
- Cancer cell–selective in vivo near infrared photoimmunotherapy targeting specific membrane moleculesNature Medicine, 2011
- Cytocompatible click-based hydrogels with dynamically tunable properties through orthogonal photoconjugation and photocleavage reactionsNature Chemistry, 2011
- The Shape Effect of Mesoporous Silica Nanoparticles on Biodistribution, Clearance, and Biocompatibility in VivoACS Nano, 2011
- Ruthenium(II) Polyimine Complexes with a Long‐Lived 3IL Excited State or a 3MLCT/3IL Equilibrium: Efficient Triplet Sensitizers for Low‐Power UpconversionAngewandte Chemie, 2011
- The Triplet State of fac-Ir(ppy)3Inorganic Chemistry, 2010
- Photoactive molecules for applications in molecular imaging and cell biologyChemical Society Reviews, 2010
- A route to brightly fluorescent carbon nanotubes for near-infrared imaging in miceNature Nanotechnology, 2009
- Entrapment of Ovalbumin into Liposomes—Factors Affecting Entrapment Efficiency, Liposome Size, and Zeta PotentialJournal of Liposome Research, 2008
- Absorption and emission spectroscopic characterization of platinum-octaethyl-porphyrin (PtOEP)Chemical Physics, 2006