Hematopoiesis is regulated by a diverse cellular of BM microenvironment which supports stepwise multi-potent stem cells differentiation as well as maturation of progenitors and precursors into mature blood cells. Some imbalances between virus inherent transforming abilities and the host immune system can lead into the various diseases development. In this case, hematopoietic dynamics are perturbed during inflammation that we want to know exactly about the HSC niche interaction in the situation which can occur as a result. Here we discuss about some infections have deleterious effects injuring hematopoietic stem cell , inefficient hematopoiesis and also destruction of the cells and then can go to the remodeling of bone marrow microenvironment and ultimately change to malignancy. So it is important to demonstrate a BM microenvironment critical role in the response to infection.