Molecular and Cellular Mechanisms of Human Astrocytoma Progression: Advances in Knowledge to Reach Therapeutic Horizons
Open Access
- 30 September 2020
- Vol. 9 (10), 2216
- https://doi.org/10.3390/cells9102216
Abstract
Human astrocytic tumors are primary central nervous system (CNS) tumors that arise either from astrocytes or from precursor cells. A growing number of epidemiological and incidence studies in different countries underlined that, in addition to increasing economic costs for health systems, these cancers are still representing one of the main hurdles in developing a successful therapeutic goal for patients. On the other hand, new-omics technologies are offering customized instruments and more and more advantageous results toward personalized medicine approaches, underlining the concept that each tumor mass undergoes a peculiar transformation process under the control of specific genes’ and proteins’ functional signatures. The main aim of this Special Issue was to collect novel contributions in the wide field of human tumor astrocytic basic and translational research, to suggest further potential therapeutic targets/strategies that might interfere, possibly at the earliest stage of transformation, with the tumor progression, and to increase the molecular-based arsenal to counteract the prognostic poverty of high-grade astrocytic tumors.This publication has 19 references indexed in Scilit:
- Large-Scale Drug Screening in Patient-Derived IDHmut Glioma Stem Cells Identifies Several Efficient Drugs among FDA-Approved Antineoplastic AgentsCells, 2020
- Emerging Role of Cellular Prion Protein in the Maintenance and Expansion of Glioma Stem CellsCells, 2019
- Hypoxia and EGF Stimulation Regulate VEGF Expression in Human Glioblastoma Multiforme (GBM) Cells by Differential Regulation of the PI3K/Rho-GTPase and MAPK PathwaysCells, 2019
- Acetylcholine Receptor Activation as a Modulator of Glioblastoma InvasionCells, 2019
- Adenosine A3 receptor elicits chemoresistance mediated by multiple resistance-associated protein-1 in human glioblastoma stem-like cellsOncotarget, 2016
- Epithelial-mesenchymal transition in glioblastoma progressionOncology Letters, 2016
- Oligodendrocyte Precursor Cells Modulate the Neuronal Network by Activity-Dependent Ectodomain Cleavage of Glial NG2PLoS Biology, 2014
- Silencing of cellular prion protein (PrPC) expression by DNA-antisense oligonucleotides induces autophagy-dependent cell death in glioma cellsAutophagy, 2011
- Sonodynamic therapy with 5-aminolevulinic acid and focused ultrasound for deep-seated intracranial glioma in rat.2011
- Biochemical Signatures of Doppel Protein in Human Astrocytomas to Support Prediction in Tumor MalignancyJournal of Biomedicine and Biotechnology, 2010