Stink bean (Parkia speciosa) empty pod: a potent natural antidiabetic agent for the prevention of pancreatic and hepatorenal dysfunction in high fat diet/streptozotocin-induced type 2 diabetes in rats
- 2 January 2021
- journal article
- research article
- Published by Taylor & Francis Ltd in Archives of Physiology and Biochemistry
- Vol. 129 (1), 261-267
- https://doi.org/10.1080/13813455.2021.1876733
Abstract
The present study investigated the effect of polyphenol-rich extract of Parkia speciosa (PPS) against pancreatic and hepatorenal dysfunction in high-fat diet (HFD)/streptozotocin (STZ)-induced diabetes. Diabetic rats were treated with PPS (100 and 400 mg/kg) and glibenclamide. The results revealed that diabetic rats displayed marked hyperglycaemia, hyperlipidaemia, hypoinsulinemia as well as alterations in serum renal and kidney function markers. Furthermore, diabetic rats showed significant increase in hepatorenal level of malonaldehyde as well as suppression of antioxidant enzyme activities. Whereas, diabetic rats that received PPS displayed marked attenuation in most of the aforementioned parameters compared to the untreated diabetic rats. Additionally, histological examination revealed restoration of histopathological alterations of the pancreas, liver, and kidney of PPS treated diabetic rats. In conclusion, the results demonstrated that PPS could decrease serum lipids and blood glucose level, enhance insulin level and hepatorenal antioxidant capacity, as well as ameliorate hepatorenal dysfunction in rats.Keywords
This publication has 41 references indexed in Scilit:
- Lipoprotein lipase links vitamin D, insulin resistance, and type 2 diabetes: a cross-sectional epidemiological studyCardiovascular Diabetology, 2013
- Parkia speciosaHassk.: A Potential PhytomedicineEvidence-Based Complementary and Alternative Medicine, 2013
- Antibacterial activity of Thai edible plants against gastrointestinal pathogenic bacteria and isolation of a new broad spectrum antibacterial polyisoprenylated benzophenone, chamuangoneFood Chemistry, 2012
- Oxidative Stress and Diabetic ComplicationsCirculation Research, 2010
- Hemagglutinating activity of proteins fromParkia speciosaseedsPharmaceutical Biology, 2009
- Hypoglycemic and hypolipidemic effects of flavonoid rich extract from Eugenia jambolana seeds on streptozotocin induced diabetic ratsFood and Chemical Toxicology, 2008
- The mechanisms of alloxan- and streptozotocin-induced diabetesDiabetologia, 2007
- Postprandial regulation of blood lipids and adipose tissue lipoprotein lipase in type 2 diabetes patients and healthy control subjectsAtherosclerosis, 2003
- Formation of thiazolidine-4-carboxyiic acid (thioproline), an effective nitrite-trapping agent in human body, in Parkia speciosa seeds and other edible leguminous seeds in ThailandFood Chemistry, 1996
- Lipoprotein lipase in diabetesDiabetes/Metabolism Research and Reviews, 1987