Emergence of SGLT2 Inhibitors as Powerful Antioxidants in Human Diseases
Open Access
- 22 July 2021
- journal article
- review article
- Published by MDPI AG in Antioxidants
- Vol. 10 (8), 1166
- https://doi.org/10.3390/antiox10081166
Abstract
Sodium-glucose cotransporter 2 (SGLT2) inhibitors are a new class of oral glucose-lowering agents. Apart from their glucose-lowering effects, large clinical trials assessing certain SGLT2 inhibitors have revealed cardiac and renal protective effects in non-diabetic patients. These excellent outcomes motivated scientists and clinical professionals to revisit their underlying mechanisms. In addition to the heart and kidney, redox homeostasis is crucial in several human diseases, including liver diseases, neural disorders, and cancers, with accumulating preclinical studies demonstrating the therapeutic benefits of SGLT2 inhibitors. In the present review, we aimed to update recent advances in the antioxidant roles of SGLT2 inhibitors in common but debilitating human diseases. We anticipate that this review will guide new research directions and novel therapeutic strategies for diabetes, cardiovascular diseases, nephropathies, liver diseases, neural disorders, and cancers in the era of SGLT2 inhibitors.Keywords
Funding Information
- Kaohsiung Chang Gung Memorial Hospital (CMRPG8K1321 and CMRPG8J0061)
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