Case Report: Efficacy of Rituximab in a Patient With Familial Mediterranean Fever and Multiple Sclerosis
Open Access
- 6 January 2021
- journal article
- research article
- Published by Frontiers Media SA in Frontiers in Neurology
Abstract
Familial Mediterranean Fever (FMF) is a genetic autoinflammatory disease characterized by recurrent episodes of fever and serositis caused by mutations in the MEFV gene, while Multiple Sclerosis (MS) is an inflammatory demyelinating disease of the CNS with genetic and environmental etiology. The two diseases rarely occur in association with relevant implications for clinical management and drug choice. In this paper, we present the case of a 53-year-old male with an autosomal dominant FMF since childhood who presented acute paresthesia at the right part of the body. He performed a brain and spinal cord MRI, which showed multiple brain lesions and a gd-enhancing lesion in the cervical spinal cord, and then received a diagnosis of MS. He then started Interferonβ-1a which was effective but not tolerated and caused hepatotoxicity, and then shifted to Rituximab with 3-month clinical and neuroradiological efficacy.This publication has 22 references indexed in Scilit:
- Class II HLA interactions modulate genetic risk for multiple sclerosisNature Genetics, 2015
- Genetic contribution to multiple sclerosis risk among Ashkenazi Jews.BMC Medical Genetics, 2015
- Serum neurofilament light chain levels are increased in patients with a clinically isolated syndromeJournal of Neurology, Neurosurgery & Psychiatry, 2015
- Efficacy of the anti–IL-6 receptor antibody tocilizumab in neuromyelitis opticaNeurology, 2014
- The possible underlying pathophysiological mechanisms for development of multiple sclerosis in familial Mediterranean feverMedical Hypotheses, 2012
- Rituximab Treatment for PR3-ANCA-Positive Membranoproliferative Glomerulonephritis Associated with Adult-Onset Periodic Fever SyndromeCase Reports in Nephrology and Urology, 2012
- Subcutaneous Recombinant Interferon-β-1a (Rebif®)Drugs, 2011
- Familial Mediterranean fever (FMF) and multiple sclerosis: an association study in one of the world’s largest FMF cohortsEuropean Journal of Neurology, 2011
- Genomic profiling of interpopulation diversity guides prioritization of candidate-genes for autoimmunityGenes & Immunity, 2004
- A candidate gene for familial Mediterranean feverNature Genetics, 1997