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A Case of Hemophagocytic Lymphohistiocytosis Induced by Regorafenib

Marion Jaffrelot, Noémie Gadaud, Jean-Pierre Delord, Carlos Gomez-Roca, Sarah Bétrian
Archives of Clinical and Medical Case Reports , Volume 5, pp 96-100; doi:10.26502/acmcr.96550332

Abstract: Hemophagocytic lymphohistiocytosis (HLH) is a rare and severe condition of immune dysregulation characterized by severe organ damage induced by a hyperinflammatory response and uncontrolled T-cell and macrophage activation. Secondary HLH, also known as macrophage activation syndrome, commonly presents in adulthood and characterized by acquired immune dysfunction in response to infections, malignancies, or autoinflammatory/autoimmune disorders. Secondary HLH induced by regorafenib has not been yet described. Here we report a case of HLH induced by regorafenib, confirmed by clinical, laboratory and histopathological findings, with typical results on bone marrow aspiration.
Keywords: Macrophage / bone marrow / HLH / adulthood / dysregulation / Uncontrolled / hemophagocytic / Lymphohistiocytosis / Induced by Regorafenib

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