Short-chain fatty acid, acylation and cardiovascular diseases
- 27 March 2020
- journal article
- review article
- Published by Portland Press Ltd. in Clinical Science
- Vol. 134 (6), 657-676
- https://doi.org/10.1042/cs20200128
Abstract
Cardiovascular diseases (CVDs) are the leading cause of morbidity and mortality worldwide. Metabolic dysfunction is a fundamental core mechanism underlying CVDs. Previous studies generally focused on the roles of long-chain fatty acids (LCFAs) in CVDs. However, a growing body of study has implied that short-chain fatty acids (SCFAs: namely propionate, malonate, butyrate, 2-hydroxyisobutyrate (2-HIBA), β-hydroxybutyrate, crotonate, succinate, and glutarate) and their cognate acylations (propionylation, malonylation, butyrylation, 2-hydroxyisobutyrylation, β-hydroxybutyrylation, crotonylation, succinylation, and glutarylation) participate in CVDs. Here, we attempt to provide an overview landscape of the metabolic pattern of SCFAs in CVDs. Especially, we would focus on the SCFAs and newly identified acylations and their roles in CVDs, including atherosclerosis, hypertension, and heart failure.Keywords
This publication has 168 references indexed in Scilit:
- The Hallmarks of AgingCell, 2013
- The gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR43Nature Communications, 2013
- Lysine Succinylation and Lysine Malonylation in HistonesMolecular & Cellular Proteomics, 2012
- Identification of 67 Histone Marks and Histone Lysine Crotonylation as a New Type of Histone ModificationCell, 2011
- Identification of lysine succinylation as a new post-translational modificationNature Chemical Biology, 2010
- Molecular Characterization of Propionyllysines in Non-histone ProteinsMolecular & Cellular Proteomics, 2009
- Leptin Resistance: A Possible Interface of Inflammation and Metabolism in Obesity-Related Cardiovascular DiseaseJournal of the American College of Cardiology, 2008
- The endogenous mitochondrial complex II inhibitor malonate regulates mitochondrial ATP-sensitive potassium channels: Implications for ischemic preconditioningBiochimica et Biophysica Acta (BBA) - Bioenergetics, 2008
- Dietary fatty acids and cardiovascular disease: An epidemiological approachProgress in Lipid Research, 2008
- Lysine Propionylation and Butyrylation Are Novel Post-translational Modifications in HistonesMolecular & Cellular Proteomics, 2007