Paediatric gastrointestinal disorders in SARS-CoV-2 infection: Epidemiological and clinical implications
Open Access
- 28 April 2021
- journal article
- review article
- Published by Baishideng Publishing Group Inc. in World Journal of Gastroenterology
- Vol. 27 (16), 1716-1727
- https://doi.org/10.3748/wjg.v27.i16.1716
Abstract
The coronavirus disease 2019 (COVID-19) pandemic is a threat worldwide for individuals of all ages, including children. Gastrointestinal manifestations could be the initial presenting manifestation in many patients, especially in children. These symptoms are more common in patients with severe disease than in patients with non-severe disease. Approximately 48.1% of patients had a stool sample that was positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral RNA. Children typically form 1%-8% of all laboratory-confirmed cases of SARS-CoV-2. Gastrointestinal manifestations of COVID-19 in children are not rare, with a prevalence between 0 and 88%, and a wide variety of presentations, including diarrhoea, vomiting, and abdominal pain, can develop before, with or after the development of respiratory symptoms. Atypical manifestations such as appendicitis or liver injury could also appear, especially in the presence of multisystem inflammatory disease. In this review, we discussed the epidemiology of COVID-19 gastrointestinal diseases in children as well as their implications on the diagnosis, misdiagnosis, prognosis, and faecal-oral transmission route of COVID-19 and the impact of gastrointestinal diseases on the gut microbiome, child nutrition, and disease management.Keywords
This publication has 66 references indexed in Scilit:
- Clinical findings in a group of patients infected with the 2019 novel coronavirus (SARS-Cov-2) outside of Wuhan, China: retrospective case seriesBMJ, 2020
- Clinical features of patients infected with 2019 novel coronavirus in Wuhan, ChinaThe Lancet, 2020
- Stent placement with iodine-125 seeds strand effectively extends the duration of stent patency and survival in patients with unresectable malignant obstructive jaundiceScandinavian Journal of Gastroenterology, 2020
- Virus–virus interactions impact the population dynamics of influenza and the common coldProceedings of the National Academy of Sciences of the United States of America, 2019
- BCG-Induced Cross-Protection and Development of Trained Immunity: Implication for Vaccine DesignFrontiers in Immunology, 2019
- ESPEN guideline on clinical nutrition in the intensive care unitClinical Nutrition, 2018
- The gut–liver axis and the intersection with the microbiomeNature Reviews Gastroenterology & Hepatology, 2018
- ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammationNature, 2012
- Gut-associated lymphoid tissue–primed CD4+ T cells display CCR9-dependent and -independent homing to the small intestineBlood, 2006
- Viral shedding patterns of coronavirus in patients with probable severe acute respiratory syndromeThe Lancet, 2004