microRNA-21: a key modulator in oncogenic viral infections
- 4 May 2021
- journal article
- review article
- Published by Taylor & Francis Ltd in RNA Biology
- Vol. 18 (5), 809-817
- https://doi.org/10.1080/15476286.2021.1880756
Abstract
Oncogenic viruses are associated with approximately 15% of human cancers. In viral infections, microRNAs play an important role in host-pathogen interactions. miR-21 is a highly conserved non-coding RNA that not only regulates the development of oncogenic viral diseases, but also responds to the regulation of intracellular signal pathways. Oncogenic viruses, including HBV, HCV, HPV, and EBV, co-evolve with their hosts and cause persistent infections. The upregulation of host miR-21 manipulates key cellular pathways to evade host immune responses and then promote viral replication. Thus, a better understanding of the role of miR-21 in viral infections may help us to develop effective genetically-engineered oncolytic virus-based therapies against cancer.Funding Information
- National Natural Science Foundation of China (U1703104)
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