The ENIGMA Brain Injury working group: approach, challenges, and potential benefits

Abstract
The Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) consortium brings together researchers from around the world to try to identify the genetic underpinnings of brain structure and function, along with robust, generalizable effects of neurological and psychiatric disorders. The recently-formed ENIGMA Brain Injury working group includes 10 subgroups, based largely on injury mechanism and patient population. This introduction to the special issue summarizes the history, organization, and objectives of ENIGMA Brain Injury, and includes a discussion of strategies, challenges, opportunities and goals common across 6 of the subgroups under the umbrella of ENIGMA Brain Injury. The following articles in this special issue, including 6 articles from different subgroups, will detail the challenges and opportunities specific to each subgroup.
Funding Information
  • National Institute of Neurological Disorders and Stroke (K99 NS096116)
  • US Army Medical Research and Materiel Command (PT12051)
  • U.S. Department of Veterans Affairs (I01 RX002174)