Analysis of Liver Function Biomarkers and Histopathology in Plasmodium Berghei-Infected Albino Mice Treated with Sodium Bicarbonate

Abstract

Malaria still remains an endemic disease especially in Sub-saharan Africa. The current study was aimed at evaluating liver function biomarkers and histology in albino mice following their infection with Plasmodium berghei and treated with Sodium Bicarbonate. Twenty mice were divided into five groups of four each. Groups 1; normal control, group 2; infected with P. berghei, untreated, groups 3, 4, 5; infected, treated 84mg/kg NaHCO₃ once, twice and thrice respectively. Blood samples and liver were collected for analysis of liver function biomarkers and histopathology by standard procedures. AST was significantly (pplasmodium berghei infected liver.