Magnetic fields as a potential therapy for diabetic wounds based on animal experiments and clinical trials
Open Access
- 8 February 2021
- journal article
- review article
- Published by Wiley in Cell Proliferation
- Vol. 54 (3), e12982
- https://doi.org/10.1111/cpr.12982
Abstract
Diabetes mellitus (DM) is a chronic metabolic disorder with various complications that poses a huge worldwide healthcare burden. Wounds in diabetes, especially diabetic foot ulcers (DFUs), are difficult to manage, often leading to prolonged wound repair and even amputation. Wound management in people with diabetes is an extremely clinical and social concern. Nowadays, physical interventions gain much attention and have been widely developed in the fields of tissue regeneration and wound healing. Magnetic fields (MFs)‐based devices are translated into clinical practice for the treatment of bone diseases and neurodegenerative disorder. This review attempts to give insight into the mechanisms and applications of MFs in wound care, especially in improving the healing outcomes of diabetic wounds. First, we discuss the pathological conditions associated with chronic diabetic wounds. Next, the mechanisms involved in MFs’ effects on wounds are explored. At last, studies and reports regarding the effects of MFs on diabetic wounds from both animal experiments and clinical trials are reviewed. MFs exhibit great potential in promoting wound healing and have been practised in the management of diabetic wounds. Further studies on the exact mechanism of MFs on diabetic wounds and the development of suitable MF‐based devices could lead to their increased applications into clinical practice.Keywords
Funding Information
- National Natural Science Foundation of China (81803032, 52037007)
- Natural Science Foundation of Shaanxi Province (2019JQ632)
This publication has 141 references indexed in Scilit:
- Effect of static magnetic field on experimental dermal wound strengthIndian Journal of Plastic Surgery, 2012
- Altered Fibroblast Proliferation and Apoptosis in Diabetic Gingival WoundsJournal of Dental Research, 2010
- Factors Affecting Wound HealingJournal of Dental Research, 2010
- Pulsed electromagnetic fields accelerate wound healing in the skin of diabetic ratsBioelectromagnetics, 2010
- The Wound Healing Process: An Overview of the Cellular and Molecular MechanismsJournal of International Medical Research, 2009
- Electrical fields in wound healing—An overriding signal that directs cell migrationSeminars in Cell & Developmental Biology, 2009
- Influence of different types of electromagnetic fields on skin reparatory processes in experimental animalsLasers in Medical Science, 2008
- The role of endothelial dysfunction in the pathogenesis of impaired diabetic wound healing: A novel therapeutic target?Medical Hypotheses, 2007
- Magnetic Field Therapy: A ReviewElectromagnetic Biology and Medicine, 2007
- The effect of short, high intensity magnetic field pulses on the healing of skin wounds in ratsBioelectromagnetics, 2004