Dietary pectic substances enhance gut health by its polycomponent: A review
Open Access
- 16 February 2021
- journal article
- review article
- Published by Wiley in Comprehensive Reviews in Food Science and Food Safety
- Vol. 20 (2), 2015-2039
- https://doi.org/10.1111/1541-4337.12723
Abstract
Pectic substances, one of the cell wall polysaccharides, exist widespread in vegetables and fruits. A surge of recent research has revealed that pectic substances can inhibit gut inflammation and relieve inflammatory bowel disease symptoms. However, physiological functions of pectins are strongly structure dependent. Pectic substances are essentially heteropolysaccharides composed of homogalacturonan and rhamnogalacturonan backbones substituted by various neutral sugar sidechains. Subtle changes in the architecture of pectic substances may remarkably influence the nutritional function of gut microbiota and the host homeostasis of immune system. In this context, developing a structure–function understanding of how pectic substances have an impact on an inflammatory bowel is of primary importance for diet therapy and new drugs. Therefore, the present review has summarized the polycomponent nature of pectic substances, the activities of different pectic polymers, the effects of molecular characteristics and the underlying mechanisms of pectic substances. The immunomodulated property of pectic substances depends on not only the chemical composition but also the physical structure characteristics, such as molecular weight (Mw) and chain conformation. The potential mechanisms by which pectic substances exert their protective effects are mainly reversing the disordered gut microbiota, regulating immune cells, enhancing barrier function, and inhibiting pathogen adhesion. The manipulation of pectic substances on gut health is sophisticated, and the link between structural specificity of pectins and selective regulation needs further exploration.Keywords
Funding Information
- National Basic Research Program of China (2017YFE0122300)
This publication has 156 references indexed in Scilit:
- High-Fat Diet Reduces the Formation of Butyrate, but Increases Succinate, Inflammation, Liver Fat and Cholesterol in Rats, while Dietary Fibre Counteracts These EffectsPLOS ONE, 2013
- Bupleurum Polysaccharides Attenuates Lipopolysaccharide-Induced Inflammation via Modulating Toll-Like Receptor 4 SignalingPLOS ONE, 2013
- Soluble plantain fibre blocks adhesion and M-cell translocation of intestinal pathogensThe Journal of Nutritional Biochemistry, 2013
- Anti-inflammatory activity of pectins and their galacturonan backboneRussian Journal of Bioorganic Chemistry, 2011
- An apple oligogalactan prevents against inflammation and carcinogenesis by targeting LPS/TLR4/NF- B pathway in a mouse model of colitis-associated colon cancerCarcinogenesis: Integrative Cancer Research, 2010
- Citrus pectin affects cytokine production by human peripheral blood mononuclear cellsBiomedicine & Pharmacotherapy, 2008
- Dendritic cells in intestinal immune regulationNature Reviews Immunology, 2008
- Comparison of Carbon Nutrition for Pathogenic and Commensal Escherichia coli Strains in the Mouse IntestineInfection and Immunity, 2008
- Okra polysaccharides inhibit adhesion of Campylobacter jejuni to mucosa isolated from poultry in vitro but not in vivoAnimal Feed Science and Technology, 2007
- Protective Effect of Comaruman, a Pectin of Cinquefoil Comarum palustre L., on Acetic Acid-Induced Colitis in MiceDigestive Diseases and Sciences, 2006