Ultrasensitive Functionalized Polymeric-Nanometal Oxide Sensors for Potentiometric Determination of Ranitidine Hydrochloride
Open Access
- 3 October 2022
- Vol. 14 (19), 4150
- https://doi.org/10.3390/polym14194150
Abstract
Two metal oxide nanoparticles, magnesium oxide nanoparticles (MgONPs) and aluminum oxide nanoparticles (Al2O3NPs), were synthesized from green sources, Salvia officials and Cuminum cyminum seed extract, respectively. These nanoparticles were used for construction of potentiometric enhancement sensors employed for the estimation of ranitidine hydrochloride (RNT) in authentic powder and commercial products. The electroactive substance ranitidine-phosphotungstate (RNT-PT) was formed by combining RNT with phosphotungstic acid (PTA) in the presence of plasticizing material o-nitrophenyloctyl ether (o-NPOE). The outcomes showed that the enhanced MgO and Al2O3 nanosensors behaved linearly across the concentration ranges 1.0 × 10−9–1.0 × 10−2 and 1.0 × 10−10–1.0 × 10−2 mol L−1, respectively. However, the conventional sensor (RNT-PT) displayed a linearity over 1.0 × 10−6–1.0 × 10−2 mol L−1. Least square equations were calculated as EmV = (54.1 ± 0.5) log (RNT) + 762.33, EmV = (58.6 ± 0.2) log (RNT) + 696.48, and EmV = (52.2 ± 0.7) log (RNT) + 756.76 for enriched nanometal oxides modified and conventional sensors, respectively. The correlation coefficients of regression equations were 0.9997, 0.9995, and 0.9992 for the above suggested sensors, respectively. The recorded results showed excellent sensitivity and selectivity of the modified nanometal oxide sensors for the quantification of the analyzed drug in its authentic samples and commercial products.Funding Information
- This research was funded by Researchers Supporting Project in King Saud University supported this project and the code number is (code number is (RSP-2021/272))
This publication has 31 references indexed in Scilit:
- New Electrochemically-Modified Carbon Paste Inclusion β-Cyclodextrin and Carbon Nanotubes Sensors for Quantification of Dorzolamide HydrochlorideInternational Journal of Molecular Sciences, 2016
- Highly luminescent S,N co‐doped carbon quantum dots‐sensitized chemiluminescence on luminol–H2O2 system for the determination of ranitidineLuminescence, 2016
- Simultaneous determination of ranitidine and metronidazole in pharmaceutical formulations at poly(chromotrope 2B) modified activated glassy carbon electrodesJournal of Food and Drug Analysis, 2014
- Improved Separate Solution Method for Determination of Low Selectivity CoefficientsAnalytical Chemistry, 2014
- Applications of nanomaterials in potentiometric sensorsTrAC Trends in Analytical Chemistry, 2013
- Electrochemical sensor for ranitidine determination based on carbon paste electrode modified with oxovanadium (IV) salen complexMaterials Science and Engineering: C, 2013
- A novel method for ranitidine hydrochloride determination in aqueous solution based on fluorescence quenching of functionalised CdS QDs through photoinduced charge transfer process: Spectroscopic approachThe Analyst, 2011
- Nanostructured metal oxide-based biosensorsNPG Asia Materials, 2011
- Nanoscience, Nanotechnology, and ChemistrySmall, 2004
- Application of nanotechnology in constructionMaterials and Structures, 2004