Repression of the Type I Interferon Pathway Underlies MYC- and KRAS-Dependent Evasion of NK and B Cells in Pancreatic Ductal Adenocarcinoma
Open Access
- 1 June 2020
- journal article
- research article
- Published by American Association for Cancer Research (AACR) in Cancer Discovery
- Vol. 10 (6), 872-887
- https://doi.org/10.1158/2159-8290.cd-19-0620
Abstract
Modest overexpression of human MYC plus expression of KrasG12D drove rapid pancreatic ductal adenocarcinoma development in mice, suppressing the type I interferon response and preventing NK- and B-cell infiltration.Keywords
Other Versions
Funding Information
- Worldwide Cancer Research AICR (15-0279)
- Pancreatic Cancer UK Future Leaders Academy 2017
- European Commission Marie-Curie actions (PCIG13-GA-2013-618448)
- SERPLUC (H2020-MCSA-IF-2015-705190-NuSiCC)
- Cancer Research UK (A21139)
- Cancer Research UK (A23983)
- British Lung Foundation (BLF-APHD13-5)
- Wellcome Trust (105614/Z/14/Z)
- CRUK Glasgow Cancer Centre (A25142)
- CRUK Beatson Institute (A17196)
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