Acute Administration of Imipramine and Citalopram Increases Activity of Striatal-Enriched Tyrosine Protein Phosphatase (STEP) in Brain of Zebrafish Danio rerio
- 31 March 2021
- journal article
- research article
- Published by Springer Science and Business Media LLC in Bulletin of Experimental Biology and Medicine
- Vol. 170 (5), 627-630
- https://doi.org/10.1007/s10517-021-05120-8
Abstract
Effects of acute treatment with antidepressant drugs, imipramine and citalopram, on behavior and activity of striatal-enriched tyrosine protein phosphatase (STEP) in the whole brain of zebrafish Danio rerio were studied. Mature zebrafish were exposed for 3 h to water (control) or to solutions of 0.25, 0.5, or 1 mg/liter of imipramine or citalopram, and then their behavior was studied in novel tank test. STEP activity was assayed in the brain of animals by the difference between the rates of transformation of p-nitrophenyl phosphate to 4-nitrophenol in the absence or presence of a selective STEP inhibitor. In novel tank test, imipramine and citalopram reduced locomotor activity and increased freezing time; at this, imipramine increased the total time spent in top of the tank. Citalopram (all concentrations) and imipramine (0.5 and 1 mg/liter) increased STEP activity in zebrafish brain.Keywords
This publication has 16 references indexed in Scilit:
- Striatal-enriched Tyrosine Protein Phosphatase (STEP) in the Mechanisms of Depressive DisordersCurrent Protein & Peptide Science, 2017
- Benzopentathiepine Derivative, 8-(Trifluoromethyl)-1,2,3,4,5-Benzopentathiepin- 6-Amine Hydrochloride (TC-2153), as a Promising Antidepressant of New GenerationLetters in Drug Design & Discovery, 2017
- Сравнение поведенческих эффектов флуоксетина, имипрамина и нового психотропного препарата ТС-2153 у мышей, различающихся по наследственной предрасположенности к каталепсииЖурнал высшей нервной деятельности им. И.П. Павлова, 2015
- Antidepressant Activity of 8-(trifluoromethyl)-1,2,3,4,5-benzopentathiepin- 6-amine hydrochloride (TC-2153): Comparison with Classical AntidepressantsLetters in Drug Design & Discovery, 2013
- Behavioral and neurochemical changes in the zebrafish leopard strainGenes, Brain and Behavior, 2013
- Perspectives on experimental models of serotonin syndrome in zebrafishNeurochemistry International, 2013
- Modeling anxiety using adult zebrafish: A conceptual reviewNeuropharmacology, 2012
- Zebrafish Behavior in Novel Environments:Effects of Acute Exposure to Anxiolytic Compounds and Choice of Danio rerio LineInternational Journal of Comparative Psychology, 2010
- Characterization and Expression of Serotonin Transporter Genes in ZebrafishThe Tohoku Journal of Experimental Medicine, 2006
- Role of selective serotonin reuptake inhibitors in psychiatric disorders: a comprehensive reviewProgress in Neuro-Psychopharmacology and Biological Psychiatry, 2003