Disease-associated astrocytes in Alzheimer's disease and aging
- 26 April 2020
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature Neuroscience
- Vol. 23 (6), 701-+
- https://doi.org/10.1038/s41593-020-0624-8
Abstract
The role of non-neuronal cells in Alzheimer's disease progression has not been fully elucidated. Using single-nucleus RNA sequencing, we identified a population of disease-associated astrocytes in an Alzheimer's disease mouse model. These disease-associated astrocytes appeared at early disease stages and increased in abundance with disease progression. We discovered that similar astrocytes appeared in aged wild-type mice and in aging human brains, suggesting their linkage to genetic and age-related factors. A new subset of disease-associated astrocytes (DAAs) is identified in a mouse model of Alzheimer's disease by single-nucleus RNA sequencing. DAAs are also found in aged wild-type mice, suggesting a link to genetic and age-related factors.This publication has 37 references indexed in Scilit:
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