Early infection-induced natural antibody response
Open Access
- 15 January 2021
- journal article
- research article
- Published by Springer Science and Business Media LLC in Scientific Reports
- Vol. 11 (1), 1-15
- https://doi.org/10.1038/s41598-021-81083-0
Abstract
There remains to this day a great gap in understanding as to the role of B cells and their products—antibodies and cytokines—in mediating the protective response to Francisella tularensis, a Gram-negative coccobacillus belonging to the group of facultative intracellular bacterial pathogens. We previously have demonstrated that Francisella interacts directly with peritoneal B-1a cells. Here, we demonstrate that, as early as 12 h postinfection, germ-free mice infected with Francisella tularensis produce infection-induced antibody clones reacting with Francisella tularensis proteins having orthologs or analogs in eukaryotic cells. Production of some individual clones was limited in time and was influenced by virulence of the Francisella strain used. The phylogenetically stabilized defense mechanism can utilize these early infection-induced antibodies both to recognize components of the invading pathogens and to eliminate molecular residues of infection-damaged self cells.Funding Information
- Ministry of Defence of the Czech Republic - long-term organization development plan Medical Aspects of Weapons of Mass Destruction of the Faculty of Military Health Sciences, University of Defence.
- Ministerstvo Vnitra České Republiky (VJ01030003, VJ01030003)
- Grantová Agentura České Republiky (19-08294S, 19-08294S)
This publication has 118 references indexed in Scilit:
- Antigen-specific antibody responses in B-1a and their relationship to natural immunityProceedings of the National Academy of Sciences of the United States of America, 2012
- Role of TLR signaling inFrancisella tularensis-LPS-induced, antibody-mediated protection againstFrancisella tularensischallengeJournal of Leukocyte Biology, 2011
- Antibodies Contribute to Effective Vaccination against Respiratory Infection by Type A Francisella tularensis StrainsInfection and Immunity, 2011
- PSORTb 3.0: improved protein subcellular localization prediction with refined localization subcategories and predictive capabilities for all prokaryotesBioinformatics, 2010
- Antigen-specific B-1a antibodies induced byFrancisella tularensisLPS provide long-term protection againstF. tularensisLVS challengeProceedings of the National Academy of Sciences of the United States of America, 2009
- Cellular and humoral immunity are synergistic in protection against types A and B Francisella tularensisVaccine, 2009
- Dual role for B-1a cells in immunity to influenza virus infectionThe Journal of Experimental Medicine, 2008
- Levofloxacin rescues mice from lethal intra-nasal infections with virulent Francisella tularensis and induces immunity and production of protective antibodyVaccine, 2008
- Genome-Wide Identification ofFrancisella tularensisVirulence DeterminantsInfection and Immunity, 2007
- Transcriptome analysis of human immune responses following live vaccine strain (LVS) Francisella tularensis vaccinationMolecular Immunology, 2007