The functional organization of axonal mRNA transport and translation
- 6 December 2020
- journal article
- review article
- Published by Springer Science and Business Media LLC in Nature Reviews Neuroscience
- Vol. 22 (2), 77-91
- https://doi.org/10.1038/s41583-020-00407-7
Abstract
Axons extend for tremendously long distances from the neuronal soma and make use of localized mRNA translation to rapidly respond to different extracellular stimuli and physiological states. The locally synthesized proteins support many different functions in both developing and mature axons, raising questions about the mechanisms by which local translation is organized to ensure the appropriate responses to specific stimuli. Publications over the past few years have uncovered new mechanisms for regulating the axonal transport and localized translation of mRNAs, with several of these pathways converging on the regulation of cohorts of functionally related mRNAs - known as RNA regulons - that drive axon growth, axon guidance, injury responses, axon survival and even axonal mitochondrial function. Recent advances point to these different regulatory pathways as organizing platforms that allow the axon's proteome to be modulated to meet its physiological needs.This publication has 179 references indexed in Scilit:
- Axonal mRNA localization and local protein synthesis in nervous system assembly, maintenance and repairNature Reviews Neuroscience, 2012
- Local Translation of Extranuclear Lamin B Promotes Axon MaintenanceCell, 2012
- Arl8 and SKIP Act Together to Link Lysosomes to Kinesin-1Developmental Cell, 2011
- Limited availability of ZBP1 restricts axonal mRNA localization and nerve regeneration capacityThe EMBO Journal, 2011
- FMRP Stalls Ribosomal Translocation on mRNAs Linked to Synaptic Function and AutismCell, 2011
- Transmembrane Receptor DCC Associates with Protein Synthesis Machinery and Regulates TranslationCell, 2010
- Regulation of axonal trafficking of cytochrome c oxidase IV mRNAMolecular and Cellular Neuroscience, 2010
- Genome-wide screen reveals APC-associated RNAs enriched in cell protrusionsNature, 2008
- The endoplasmic reticulum and the unfolded protein responseSeminars in Cell & Developmental Biology, 2007
- bicoid RNA localization requires specific binding of an endosomal sorting complexNature, 2007