Bioassay-Guided Isolation and HPLC Quantification of Antiproliferative Metabolites from Stahlianthus thorelii
Open Access
- 28 January 2020
- Vol. 25 (3), 551
- https://doi.org/10.3390/molecules25030551
Abstract
In folk medicine, Stahlianthus thorelii Gagnep. has been used to treat diseases related to inflammation, ulcers, and cancer. There are no reports concerning the chemical components and bioactivities of S. thorelii; thus, this study aims to explore the phytochemicals, quantify the main compounds, and test the anticancer activity of isolates from S. thorelii. Dried rhizomes were extracted with 95% ethanol and, then, partitioned, fractionated, and isolated. On the basis of the result of the antiproliferative activity of the fractions, seven isolates were yielded and were identified by spectroscopic analyses. The inhibition of cancer proliferation was determined by an MTT assay and the deployed IC50 to value their efficacy. Seven compounds containing one new C-benzylated dihydrochalcone derivative, thorechalcone A (1) and 2–7 were isolated from S. thorelii. In terms of the bioactivity, compounds 1 and 3 displayed promising antiproliferative activity (WiDr, A549, and HepG2), with IC50 values thorelii. The validated simple, accurate, and rapid HPLC method could be deployed for the quality control of herbal drugs.This publication has 21 references indexed in Scilit:
- Evaluation of multi-activities of 14 edible species from ZingiberaceaeInternational Journal of Food Sciences and Nutrition, 2012
- Antiausterity Agents from Uvaria dac and Their Preferential Cytotoxic Activity against Human Pancreatic Cancer Cell Lines in a Nutrient-Deprived ConditionJournal of Natural Products, 2012
- Steamed ginger (Zingiber officinale): Changed chemical profile and increased anticancer potentialFood Chemistry, 2011
- In vitro and in vivo anti-Leishmania activity of polysubstituted synthetic chalconesBioorganic & Medicinal Chemistry Letters, 2010
- Isolation of Apoptosis- and Differentiation-Inducing Substances toward Human Promyelocytic Leukemia HL-60 Cells from Leaves ofJuniperus taxifoliaBioscience, Biotechnology, and Biochemistry, 2008
- Cytotoxicity, Apoptosis and DNA Damage Induced by Alpinia galanga Rhizome ExtractPlanta Medica, 2007
- Anticancer properties of panduratin A isolated from Boesenbergia pandurata (Zingiberaceae)Journal of Natural Medicines, 2006
- Screening for Antitumor Activity of 11 Species of Indonesian Zingiberaceae Using Human MCF-7 and HT-29 Cancer CellsPharmaceutical Biology, 2003
- Structures of β-senepoxide, tingtanoxide, and their diene precursors. Constituents of Uvaria ferrugineaTetrahedron Letters, 1983
- Three new flavonoids in Prunus cerasusPhytochemistry, 1977