Nanoparticle Formulation of Indocyanine Green Improves Image-Guided Surgery in a Murine Model of Breast Cancer
- 1 August 2020
- journal article
- research article
- Published by Springer Science and Business Media LLC in Molecular Imaging & Biology
- Vol. 22 (4), 891-903
- https://doi.org/10.1007/s11307-019-01462-y
Abstract
Negative surgical margins (NSMs) have favorable prognostic implications in breast tumor resection surgery. Fluorescence image-guided surgery (FIGS) has the ability to delineate surgical margins in real time, potentially improving the completeness of tumor resection. We have recently developed indocyanine green (ICG)-loaded self-assembled hyaluronic acid (HA) nanoparticles (NanoICG) for solid tumor imaging, which were shown to enhance intraoperative contrast.Keywords
Funding Information
- National Institute of Biomedical Imaging and Bioengineering (R01EB019449)
- National Cancer Institute (P50CA127297, P30CA036727)
- National Institute of General Medical Sciences (P20GM103480)
- U.S. Department of Defense (W81XWH-14-1-0567)
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