The longitudinal association between externalizing behavior and frontoamygdalar resting‐state functional connectivity in late adolescence and young adulthood
Open Access
- 20 September 2020
- journal article
- research article
- Published by Wiley in Journal of Child Psychology and Psychiatry
- Vol. 62 (7), 857-867
- https://doi.org/10.1111/jcpp.13330
Abstract
Background Externalizing behavior has been attributed, in part, to decreased frontolimbic control over amygdala activation. However, little is known about developmental trajectories of frontoamygdalar functional connectivity and its relation to externalizing behavior. The present study addresses this gap by examining longitudinal associations between adolescent and adult externalizing behavior and amygdala–anterior cingulate cortex (ACC) and amygdala–orbitofrontal cortex (OFC) resting‐state functional connectivity in a sample of 111 typically developing participants aged 11–23 at baseline. Methods Participants completed two‐to‐four data waves spaced approximately two years apart, resulting in a total of 309 data points. At each data wave, externalizing behavior was measured using the Externalizing Behavior Broadband Scale from the Achenbach Youth/Adult Self‐Report questionnaire. Resting‐state fMRI preprocessing was performed using FSL. Amygdala functional connectivity was examined using AFNI. The longitudinal association between externalizing behavior and amygdala–ACC/OFC functional connectivity was examined using linear mixed effect models in R. Results Externalizing behavior was associated with increased amygdala–ACC and amygdala–OFC resting‐state functional connectivity across adolescence and young adulthood. For amygdala–ACC connectivity, externalizing behavior at baseline primarily drove this association, whereas for amygdala–OFC functional connectivity, change in externalizing behavior relative to baseline drove the main effect of externalizing behavior on amygdala–OFC functional connectivity. No evidence was found for differential developmental trajectories of frontoamygdalar connectivity for different levels of externalizing behavior (i.e., age‐by‐externalizing behavior interaction effect). Conclusions Higher externalizing behavior is associated with increased resting‐state attunement between the amygdala and ACC/OFC, perhaps indicating a generally more vigilant state for neural networks important for emotional processing and control.Funding Information
- National Institute on Drug Abuse (R01 DA 017843)
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek (446‐16‐022)
This publication has 52 references indexed in Scilit:
- The anterior cingulate cortex: an integrative hub for human socially-driven interactionsFrontiers in Neuroscience, 2013
- Reduced amygdala–orbitofrontal connectivity during moral judgments in youths with disruptive behavior disorders and psychopathic traitsPsychiatry Research: Neuroimaging, 2011
- Cross-species studies of orbitofrontal cortex and value-based decision-makingNature Neuroscience, 2011
- Developmental associations between externalizing behaviors, peer delinquency, drug use, perceived neighborhood crime, and violent behavior in urban communitiesAggressive Behavior, 2011
- Emergence of resting state networks in the preterm human brainProceedings of the National Academy of Sciences of the United States of America, 2010
- Three-dimensional reconstruction and segmentation of intact Drosophila by ultramicroscopyFrontiers in Systems Neuroscience, 2010
- Whole brain resting-state analysis reveals decreased functional connectivity in major depressionFrontiers in Systems Neuroscience, 2010
- Attention-deficit/hyperactivity disorder is characterized by a delay in cortical maturationProceedings of the National Academy of Sciences of the United States of America, 2007
- Adolescents’ performance on delay and probability discounting tasks: Contributions of age, intelligence, executive functioning, and self-reported externalizing behaviorPersonality and Individual Differences, 2007
- Amygdala–frontal connectivity during emotion regulationSocial Cognitive and Affective Neuroscience, 2007