Tumor-on-a-chip: from bioinspired design to biomedical application
Open Access
- 21 June 2021
- journal article
- review article
- Published by Springer Science and Business Media LLC in Microsystems & Nanoengineering
- Vol. 7 (1), 1-23
- https://doi.org/10.1038/s41378-021-00277-8
Abstract
Cancer is one of the leading causes of human death, despite enormous efforts to explore cancer biology and develop anticancer therapies. The main challenges in cancer research are establishing an efficient tumor microenvironment in vitro and exploring efficient means for screening anticancer drugs to reveal the nature of cancer and develop treatments. The tumor microenvironment possesses human-specific biophysical and biochemical factors that are difficult to recapitulate in conventional in vitro planar cell models and in vivo animal models. Therefore, model limitations have hindered the translation of basic research findings to clinical applications. In this review, we introduce the recent progress in tumor-on-a-chip devices for cancer biology research, medicine assessment, and biomedical applications in detail. The emerging tumor-on-a-chip platforms integrating 3D cell culture, microfluidic technology, and tissue engineering have successfully mimicked the pivotal structural and functional characteristics of the in vivo tumor microenvironment. The recent advances in tumor-on-a-chip platforms for cancer biology studies and biomedical applications are detailed and analyzed in this review. This review should be valuable for further understanding the mechanisms of the tumor evolution process, screening anticancer drugs, and developing cancer therapies, and it addresses the challenges and potential opportunities in predicting drug screening and cancer treatment.Keywords
Funding Information
- The 100 Talents program of Sun Yat-Sen University
- Guangdong Basic and Applied Basic Research Foundation of China
- Open Fund of State Key Laboratory of Biocontrol at Sun Yat-sen University
- National Natural Science Foundation of China (81770608)
This publication has 227 references indexed in Scilit:
- Genomic responses in mouse models poorly mimic human inflammatory diseasesProceedings of the National Academy of Sciences of the United States of America, 2013
- Towards personalized medicine with a three-dimensional micro-scale perfusion-based two-chamber tissue model systemBiomaterials, 2012
- Tumor Microenvironment Complexity: Emerging Roles in Cancer TherapyCancer Research, 2012
- Towards automated production and drug sensitivity testing using scaffold‐free spherical tumor microtissuesBiotechnology Journal, 2011
- Transition to invasion in breast cancer: a microfluidic in vitro model enables examination of spatial and temporal effectsIntegrative Biology, 2011
- Novel PDMS cylindrical channels that generate coaxial flow, and application to fabrication of microfibers and particlesLab on a Chip, 2010
- Assay of glioma cell responses to an anticancer drug in a cell-based microfluidic deviceMicrofluidics and Nanofluidics, 2010
- Soft lithography for micro- and nanoscale patterningNature Protocols, 2010
- Towards a human-on-chip: Culturing multiple cell types on a chip with compartmentalized microenvironmentsLab on a Chip, 2009
- Why are tumour blood vessels abnormal and why is it important to know?British Journal of Cancer, 2009