Aquaculture production has increased considerably nowadays due to intensive culture and deploying biological techniques. Seafood is expected to be the future trustworthy food source that is going to serve the poor. Sustainability can be achieved by providing the nutritious and completely balanced feed. Aquaculture has many issues like efficiency in feeding, prevention of overfeeding for fish, avoiding wastage of food, maintaining good health conditions in fish, using advanced biotechnological methods, and fish consumption connected with human health. Prevention of nutrient deficiency and the occurrence of disease in fish can be achieved only by providing adequate nutrients. This study shows the effect of balanced feed on fish health, well-being, and prevention of disease in fishes.