Monocyte-to-lymphocyte ratio and platelet-to-lymphocyte ratio in opioid use disorder and marijuana use disorder
- 1 January 2020
- journal article
- research article
- Published by Kare Publishing in Dusunen Adam the Journal of Psychiatry and Neurological Sciences
- Vol. 33 (2), 139-145
- https://doi.org/10.14744/dajpns.2020.00073
Abstract
Objective: Various methods are used to determine a person’s opioid/marijuana status. However, more specific and sensitive markers are needed that are easily applicable and accessible. Complete blood count (CBC) is a convenient method to be used for this purpose. In this study, we investigated the relationship between CBC values – particularly monocyte-to-lymphocyte ratio (MLR) and platelet-to-lymphocyte ratio (PLR) – and opioid/marijuana use disorder. Method: We compared CBC values of 56 male patients diagnosed with opioid use disorder (OUD), 56 male patients diagnosed with marijuana use disorder (MUD), and 56 healthy subjects. Results: The percentage of monocytes was significantly higher in the MUD group compared to the OUD group (p=0.010). The monocyte count was significantly different in the MUD group compared to the other two groups (p=0.018). MLR was significantly higher in the MUD group than in the OUD group (p=0.049). PLR was significantly different from the other two groups in the OUD group (p=0.038). In the MUD group, percentage of monocytes was declining with age (r=-0.474, p=0.011). The area under the receiver operating characteristic curve of the monocyte count value for MUD was 0.670. Conclusion: Measurements like lymphocyte- and monocyte-related ratios in OUD and MUD can be important in monitoring and detecting the substance and for differentiating between acute and chronic conditions. In order to clarify the subject, further studies with fewer limitations are needed. Amaç: Opioit/esrar ile ilgili durumların belirlenmesinde kullanılan çeşitli yöntemler vardır. Bununla birlikte, kolayca uygulanabilir ve erişilebilir olan daha özgül ve duyarlı belirteçlere ihtiyaç vardır. Tam kan sayımı (TKS), bu amaç için kullanılabilecek uygun bir yöntemdir. Bu çalışmada, monosit lenfosit oranı (MLO) ile trombosit lenfosit oranı (TLO) başta olmak üzere TKS değerleri ve opioit/esrar kullanım bozukluğu arasındaki ilişkiyi araştırdık. Yöntem: Opioit kullanım bozukluğu (OKB) tanılı 56 erkek hasta, esrar kullanım bozukluğu (EKB) tanılı 56 erkek hasta ve 56 sağlıklı birey karşılaştırıldı. Bulgular: Monosit yüzdesi (MONO%) OKB grubuna göre EKB grubunda anlamlı olarak daha yüksekti (p=0.010). Monosit sayısı (MONO) EKB grubunda diğer iki gruptan anlamlı olarak farklıydı (p=0.018). MLO, EKB grubunda OKB grubuna göre anlamlı olarak yüksekti (p=0.049). TLO, OKB grubunda diğer iki gruptan anlamlı olarak farklıydı (p=0.038). EKB grubunda MONO% yaşla birlikte azalıyordu (r=-0.474, p=0.011). EKB’de MONO değerinin ROC eğrisinin altında kalan alan 0.670 idi. Sonuç: EKB ve OKB’de lenfosit ile ilişkili oranlar, maddenin takibi, saptanması ve akut/kronik durumların ayırımında önemli olabilir. Konuyu açıklığa kavuşturmak için, daha az kısıtlılığa sahip daha ileri çalışmalara ihtiyaç vardır.Keywords
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