A Tuneable, Photocurable, Poly(Caprolactone)-Based Resin for Tissue Engineering—Synthesis, Characterisation and Use in Stereolithography
Open Access
- 24 February 2021
- Vol. 26 (5), 1199
- https://doi.org/10.3390/molecules26051199
Abstract
Stereolithography is a useful additive manufacturing technique for the production of scaffolds for tissue engineering. Here we present a tuneable, easy-to-manufacture, photocurable resin for use in stereolithography, based on the widely used biomaterial, poly(caprolactone) (PCL). PCL triol was methacrylated to varying degrees and mixed with photoinitiator to produce a photocurable prepolymer resin, which cured under UV light to produce a cytocompatible material. This study demonstrates that poly(caprolactone) methacrylate (PCLMA) can be produced with a range of mechanical properties and degradation rates. By increasing the degree of methacrylation (DM) of the prepolymer, the Young’s modulus of the crosslinked PCLMA could be varied from 0.12–3.51 MPa. The accelerated degradation rate was also reduced from complete degradation in 17 days to non-significant degradation in 21 days. The additive manufacturing capabilities of the resin were demonstrated by the production of a variety of different 3D structures using micro-stereolithography. Here, β-carotene was used as a novel, cytocompatible photoabsorber and enabled the production of complex geometries by giving control over cure depth. The PCLMA presented here offers an attractive, tuneable biomaterial for the production of tissue engineering scaffolds for a wide range of applications.Keywords
Funding Information
- Engineering and Physical Sciences Research Council (EP/L505055/1)
This publication has 85 references indexed in Scilit:
- Three-dimensional laser micro- and nano-structuring of acrylated poly(ethylene glycol) materials and evaluation of their cytoxicity for tissue engineering applicationsActa Biomaterialia, 2010
- Mechanical and microstructural properties of polycaprolactone scaffolds with one-dimensional, two-dimensional, and three-dimensional orthogonally oriented porous architectures produced by selective laser sinteringActa Biomaterialia, 2010
- Fabrication of 3D biocompatible/biodegradable micro-scaffolds using dynamic mask projection microstereolithographyJournal of the American Academy of Dermatology, 2009
- Photo-crosslinked poly(ε-caprolactone fumarate) networks for guided peripheral nerve regeneration: Material properties and preliminary biological evaluationsActa Biomaterialia, 2009
- Photo-crosslinked poly(ɛ-caprolactone fumarate) networks: Roles of crystallinity and crosslinking density in determining mechanical propertiesPolymer, 2008
- Photo-Cross-Linked Hybrid Polymer Networks Consisting of Poly(propylene fumarate) and Poly(caprolactone fumarate): Controlled Physical Properties and Regulated Bone and Nerve Cell ResponsesBiomacromolecules, 2008
- The effect of the alignment of electrospun fibrous scaffolds on Schwann cell maturationBiomaterials, 2008
- Poly(propylene fumarate) Bone Tissue Engineering Scaffold Fabrication Using Stereolithography: Effects of Resin Formulations and Laser ParametersBiomacromolecules, 2007
- Laser‐layered microfabrication of spatially patterned functionalized tissue‐engineering scaffoldsJournal of Biomedical Materials Research Part B: Applied Biomaterials, 2005
- Synthesis of bioabsorbable networks from methacrylate-endcapped polyestersPolymer, 1993