The interplay of movement and spatiotemporal variation in transmission degrades pandemic control
Open Access
- 10 November 2020
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences of the United States of America
- Vol. 117 (48), 30104-30106
- https://doi.org/10.1073/pnas.2018286117
Abstract
Successful public health regimes for COVID-19 push below unity long-term regional Rt —the average number of secondary cases caused by an infectious individual. We use a susceptible-infectious-recovered (SIR) model for two coupled populations to make the conceptual point that asynchronous, variable local control, together with movement between populations, elevates long-term regional Rt, and cumulative cases, and may even prevent disease eradication that is otherwise possible. For effective pandemic mitigation strategies, it is critical that models encompass both spatiotemporal heterogeneity in transmission and movement.Funding Information
- U.S. Department of Agriculture (2017-67013-26870)
- National Science Foundation (DEB‐1655555)
- University of Florida Foundation (None applicable)
This publication has 12 references indexed in Scilit:
- Assessing the impact of coordinated COVID-19 exit strategies across EuropeScience, 2020
- Inferring change points in the spread of COVID-19 reveals the effectiveness of interventionsScience, 2020
- The implications of silent transmission for the control of COVID-19 outbreaksProceedings of the National Academy of Sciences of the United States of America, 2020
- Substantial undocumented infection facilitates the rapid dissemination of novel coronavirus (SARS-CoV-2)Science, 2020
- Spread and dynamics of the COVID-19 epidemic in Italy: Effects of emergency containment measuresProceedings of the National Academy of Sciences of the United States of America, 2020
- Impact of international travel and border control measures on the global spread of the novel 2019 coronavirus outbreakProceedings of the National Academy of Sciences of the United States of America, 2020
- The exacerbation of Ebola outbreaks by conflict in the Democratic Republic of the CongoProceedings of the National Academy of Sciences of the United States of America, 2019
- Temporal Autocorrelation Can Enhance the Persistence and Abundance of Metapopulations Comprised of Coupled SinksThe American Naturalist, 2005
- Persistent colonization and the spread of antibiotic resistance in nosocomial pathogens: Resistance is a regional problemProceedings of the National Academy of Sciences of the United States of America, 2004
- The inflationary effects of environmental fluctuations in source–sink systemsProceedings of the National Academy of Sciences of the United States of America, 2002