The Pathogenesis and Predisposing Factors of Kidney Damage Caused by Multiple Myeloma

Abstract

Kidney injury is one of the most common complications of multiple myeloma, one of the poor prognosis factors in patients with multiple myeloma, and can be the first clinical manifestation of multiple myeloma. Relevant studies have proved that kidney injury is an independent risk factor for death in patients with multiple myeloma, even though the overall survival of patients with multiple myeloma complicated with kidney injury is improved after the introduction of new anti-tumor drugs, but it was still worse than patients without renal damage. This review discussed the risk factors, pathogenesis and inducement factors of multiple myeloma-induced renal impairment, providing guidance value for early clinical prevention of multiple myeloma-related renal impair-ment, improvement of renal function in patients with multiple myeloma and overall prognosis of multiple myeloma.