Straight from the Horse’s “Mouth”: Genomic Epidemiology of an Icelandic Equine Epidemic
Open Access
- 8 November 2017
- journal article
- comment
- Published by American Society for Microbiology in mBio
- Vol. 8 (5), e01613-17
- https://doi.org/10.1128/mbio.01613-17
Abstract
Despite tight biosecurity measures, an outbreak of respiratory disease rapidly spread across the Icelandic equine population in 2010. Horse transportation was brought to a halt in order to contain the spread of the infectious agent. In a recent article, Björnsdóttir and colleagues (S. Björnsdóttir et al., mBio 8:e00826-17, 2017, https://doi.org/10.1128/mBio.00826-17 ) employ the power and resolution of “genomic epidemiology,” the combination of whole genomic sequencing and epidemiological approaches, to examine the source and spread of the outbreak. Intriguingly, the outbreak was not viral in origin, but linked to a bacterial “commensal” Streptococcus equi subsp. zooepidemicus infection. A national sampling strategy coupled with population genomics revealed that the outbreak was most likely driven by a S. equi subsp. zooepidemicus sequence type 209 (ST209) infection that spread nationally from a single source. This retrospective study demonstrates the power of genomics applied on a national scale to unravel the cause of a significant biosecurity threat.This publication has 20 references indexed in Scilit:
- Distinguishable Epidemics of Multidrug-Resistant Salmonella Typhimurium DT104 in Different HostsScience, 2013
- Outbreak of upper respiratory disease in horses caused by Streptococcus equi subsp. zooepidemicus ST-24Veterinary Microbiology, 2013
- Human infections with the emerging avian influenza A H7N9 virus from wet market poultry: clinical analysis and characterisation of viral genomeThe Lancet, 2013
- A Culture-Independent Sequence-Based Metagenomics Approach to the Investigation of an Outbreak of Shiga-Toxigenic Escherichia coli O104:H4JAMA, 2013
- Outsmarting OutbreaksScience, 2012
- Genetic Diversity of Streptococcus equi subsp. zooepidemicus and Doxycycline Resistance in Kennelled DogsJournal of Clinical Microbiology, 2012
- Recent human-to-poultry host jump, adaptation, and pandemic spread of Staphylococcus aureusProceedings of the National Academy of Sciences of the United States of America, 2009
- Emergence and pandemic potential of swine-origin H1N1 influenza virusNature, 2009
- A Clonal Outbreak of Acute Fatal Hemorrhagic Pneumonia in Intensively Housed (Shelter) Dogs Caused byStreptococcus equisubsp.zooepidemicusVeterinary Pathology, 2008
- Comparison of the phenotypes of Streptococcus zooepidemicus isolated from tonsils of healthy horses and specimens obtained from foals and donkeys with pneumoniaAmerican Journal of Veterinary Research, 2000