Evaluation of the Accuracy of 99DOTS, a Novel Cellphone-based Strategy for Monitoring Adherence to Tuberculosis Medications: Comparison of DigitalAdherence Data With Urine Isoniazid Testing

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Abstract
99DOTS is a cellphone-based strategy for monitoring tuberculosis medication adherence. In a sample of 597 Indian patients with tuberculosis, we compared 99DOTS’ adherence assessments against results of urine isoniazid tests collected during unannounced home visits. 99DOTS had suboptimal accuracy for measuring adherence, partly due to poor patient engagement with 99DOTS.
Funding Information
  • Bill and Melinda Gates Foundation (OPP1154670, OPP1154665)
  • Harvard Catalyst KL2/Catalyst Medical Investigator Training (KL2 TR001100)
  • Harvard Center for AIDS Research (5P30AI060354-13)
  • Doris Duke Clinical Scientist Development Award (2018095, K24MH114732)
  • National Institutes of Health (K24MH114732)