Degradable High Molecular Weight Monodisperse Dendritic Poly(ethylene glycols)
- 26 August 2020
- journal article
- research article
- Published by American Chemical Society (ACS) in Biomacromolecules
- Vol. 21 (10), 4294-4301
- https://doi.org/10.1021/acs.biomac.0c01089
Abstract
Poly(ethylene glycols) (PEGs) are extensively explored by the pharma industry as foundations for new therapeutic products. PEGs are typically used for their conjugation to active drugs, peptides, proteins and the like, to increase the half-life and enhance the therapeutic outcome. Considering the necessity of batch-to-batch consistency for clinical products, monodisperse PEGs are highly attractive, but are generally limited to 5 kDa as an upper molecular weight (Mw) and with an oligomer purity of 95%. By amalgamating short, monodisperse PEGs with dendritic frameworks based on bis-MPA polyesters, we showcase a robust synthetic approach to monodisperse PEGs with Mw ranging from 2 to 65 kDa. The latter is, to our knowledge, the highest Mw structure of its kind ever reported. Importantly, the dendrit-ic multifunctional connector facilitated degradability at pH 7.4 at 37 °C, which is an important feature for the delivery of therapeutic agents.Keywords
Funding Information
- Vetenskapsr?det (2010-435, 2011-5358, 2015-04779)
- Knut och Alice Wallenbergs Stiftelse (2012.0196, 2017.0300)
This publication has 37 references indexed in Scilit:
- Translating Nanotechnology from Bench to Pharmaceutical Market: Barriers, Success, and PromisesJournal of Drug Delivery, 2012
- Poly(ethylene glycol) in Drug Delivery: Pros and Cons as Well as Potential AlternativesAngewandte Chemie, 2010
- PEGylation of therapeutic proteinsBiotechnology Journal, 2010
- Bifunctional Dendrimers: From Robust Synthesis and Accelerated One‐Pot Postfunctionalization Strategy to Potential ApplicationsAngewandte Chemie, 2009
- Novel Monodisperse PEG−Dendrons as New Tools for Targeted Drug Delivery: Synthesis, Characterization and Cellular UptakeBiomacromolecules, 2005
- PEGylation, successful approach to drug deliveryDrug Discovery Today, 2005
- Safety assessment on polyethylene glycols (PEGs) and their derivatives as used in cosmetic productsToxicology, 2005
- Synthesis, Characterization, and 1H NMR Self-Diffusion Studies of Dendritic Aliphatic Polyesters Based on 2,2-Bis(hydroxymethyl)propionic Acid and 1,1,1-Tris(hydroxyphenyl)ethaneJournal of the American Chemical Society, 1996
- Hyperbranched Aliphatic PolyestersMacromolecules, 1995
- Synthesis, characterization, and curing of hyperbranched allyl ether–maleate functional ester resinsJournal of Polymer Science Part A: Polymer Chemistry, 1993