Single-dose intraoperative radiotherapy during lumpectomy for breast cancer: an innovative patient-centred treatment
Open Access
- 2 February 2021
- journal article
- editorial
- Published by Springer Science and Business Media LLC in British Journal of Cancer
- Vol. 124 (9), 1469-1474
- https://doi.org/10.1038/s41416-020-01233-5
Abstract
Summary: In the randomised TARGIT-A trial, risk-adapted targeted intraoperative radiotherapy (TARGIT-IORT) during lumpectomy was non-inferior to whole-breast external beam radiotherapy, for local recurrence. In the long-term, no difference was found in any breast cancer outcome, whereas there were fewer deaths from non-breast-cancer causes. TARGIT-IORT should be included in pre-operative consultations with eligible patients.Keywords
Funding Information
- DH | NIHR | Health Technology Assessment Programme (HTA 07/60/49, HTA 10/04/07, HTA 14/49/13)
- UCL Hospitals Charitable Foundation (-)
This publication has 40 references indexed in Scilit:
- Objective assessment of cosmetic outcome after targeted intraoperative radiotherapy in breast cancer: results from a randomised controlled trialBreast Cancer Research and Treatment, 2013
- Lumpectomy Plus Tamoxifen With or Without Irradiation in Women Age 70 Years or Older With Early Breast Cancer: Long-Term Follow-Up of CALGB 9343Journal of Clinical Oncology, 2013
- Radiotherapy or tamoxifen after conserving surgery for breast cancers of excellent prognosis: British Association of Surgical Oncology (BASO) II trialEuropean Journal of Cancer, 2013
- Risk of Ischemic Heart Disease in Women after Radiotherapy for Breast CancerThe New England Journal of Medicine, 2013
- Late radiation toxicity after intraoperative radiotherapy (IORT) for breast cancer: results from the randomized phase III trial TARGIT ABreast Cancer Research and Treatment, 2012
- Persistent pain after targeted intraoperative radiotherapy (TARGIT) or external breast radiotherapy for breast cancer: A randomized trialThe Breast, 2012
- Proposal for Standardized Definitions for Efficacy End Points in Adjuvant Breast Cancer Trials: The STEEP SystemJournal of Clinical Oncology, 2007
- Mechanisms linking obesity with cardiovascular diseaseNature, 2006
- Lumpectomy plus Tamoxifen with or without Irradiation in Women 70 Years of Age or Older with Early Breast CancerThe New England Journal of Medicine, 2004
- The christie hospital breast conservation trial: An update at 8 years from inceptionClinical Oncology, 1993