Raising Question Marks: Diagnostic anomalies with standard Oral Glucose Test

Abstract

Since the 17th century when Thomas Willis described diabetic urine as “wonder Tolerance fully sweet” like sugar or honey, which paved way for future diagnostic methodologies for diabetes. Since then diabetes diagnostics over the last century had witnessed multi-step evolution from urine glucose analysis, to oral glucose tolerance test, and introduction of glycated hemoglobin. Urine glucose analysis by means of acid hydrolysis was started was introduced by Karl Trommer, in 1841, which is considered as a landmark milestone in the laboratory diagnostics [1].