Hospitals have professional human resources in various service fields. One of them is a nurse. This study aims to determine the effect of individual characteristics, organizational factors, and job satisfaction on the performance of nurses. This type of research is analytical survey by design (cross sectional). The research sample consisted of 165 nurses with accidental sampling method. This study uses a questionnaire on organizational factors, job satisfaction, and performance. The study was conducted from November to December 2019 at Bunda Thamrin General Hospital. Bivariate data analysis using Chi-square (X2) statistical test and multivariate using logistic regression. The results showed that there was an effect (p0,05) gender (p=0,55; RR=0,38), age (p=0,29; RR=0,52), education level (p=0,32; RR=1,72), career path (p=0,08; RR=0,41), and marital status (p=0,74; RR=0,73) on nurse performance. Job satisfaction and supervision are variables that have the greatest influence on the performance of nurses. So it is important for institutions to improve the quality of supervision (increase supervisory competence, determine materials and supervision schedules) and increase job satisfaction (considering motivational and hygiene factors). In addition, it provides appropriate rewards and maintains the nurse's tenure, so that it can improve nurse performance