Meningitis and bacteremia by nonhemolytic Group B Streptococcus strain: A whole genome analysis
- 2 June 2020
- journal article
- research article
- Published by Wiley in Microbiology and Immunology
- Vol. 64 (9), 630-634
- https://doi.org/10.1111/1348-0421.12826
Abstract
Group B streptococcus (GBS) is a leading cause of neonatal infections. Most isolates are β‐hemolytic, and their activity is considered to be pivotal for GBS pathogenicity. We report a case of a neonate with meningitis caused by nonhemolytic GBS. The patient developed meningitis 3 days after birth. We performed genotyping and identified the characteristics of the strain (GCMC97051) by whole genome sequence using next generation sequencing. GCMC97051 possesses genetic alterations such as disruption of cylA by IS1381A insertion and a frameshift mutation in cylE , resulting in lack of hemolysis. Thus, nonhemolytic GBS can retain the potential to cause invasive infections.Keywords
Funding Information
- Japan Agency for Medical Research and Development (JP19fk0108103)
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