Tissue regulatory T cells
Open Access
- 31 August 2020
- journal article
- review article
- Published by Wiley in Immunology
- Vol. 161 (1), 4-17
- https://doi.org/10.1111/imm.13208
Abstract
Foxp3(+) CD4(+)regulatory T cells (Tregs) are an immune cell lineage endowed with immunosuppressive functionality in a wide array of contexts, including both anti-pathogenic and anti-self responses. In the past decades, our understanding of the functional diversity of circulating or lymphoid Tregs has grown exponentially. Only recently, the importance of Tregs residing within non-lymphoid tissues, such as visceral adipose tissue, muscle, skin and intestine, has been recognized. Not only are Tregs critical for influencing the kinetics and strength of immune responses, but the regulation of non-immune or parenchymal cells, also fall within the purview of tissue-resident or infiltrating Tregs. This review focuses on providing a systematic and comprehensive comparison of the molecular maintenance, local adaptation and functional specializations of Treg populations operating within different tissues.Keywords
Funding Information
- Medical Research Council (MR/S020918/1)
- Wellcome Trust (213401/Z/18/Z)
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