Autophagy: A Novel Horizon for Hair Cell Protection
Open Access
- 29 June 2021
- journal article
- review article
- Published by Hindawi Limited in Neural Plasticity
- Vol. 2021, 1-11
- https://doi.org/10.1155/2021/5511010
Abstract
As a general sensory disorder, hearing loss was a major concern worldwide. Autophagy is a common cellular reaction to stress that degrades cytoplasmic waste through the lysosome pathway. Autophagy not only plays major roles in maintaining intracellular homeostasis but is also involved in the development and pathogenesis of many diseases. In the auditory system, several studies revealed the link between autophagy and hearing protection. In this review, we aimed to establish the correlation between autophagy and hair cells (HCs) from the aspects of ototoxic drugs, aging, and acoustic trauma and discussed whether autophagy could serve as a potential measure in the protection of HCs.Keywords
Funding Information
- Shanghai Rising-Star Program (19QA1401800, 81870728, 82071045)
This publication has 149 references indexed in Scilit:
- Identifying MicroRNAs Involved in Degeneration of the Organ of Corti during Age-Related Hearing LossPLOS ONE, 2013
- Autophagy During Vertebrate DevelopmentCells, 2012
- New developments in aminoglycoside therapy and ototoxicityHearing Research, 2011
- MiR-34 modulates Caenorhabditis elegans lifespan via repressing the autophagy gene atg9AGE, 2011
- Short interfering RNA against STAT1 attenuates cisplatin-induced ototoxicity in the rat by suppressing inflammationCell Death & Disease, 2011
- Autophagy promotes survival of retinal ganglion cells after optic nerve axotomy in miceCell Death & Differentiation, 2011
- GSK3: a multifaceted kinase in Wnt signalingTrends in Biochemical Sciences, 2010
- Autophagy fights disease through cellular self-digestionNature, 2008
- A role for epigenetics in hearing: Establishment and maintenance of auditory specific gene expression patternsHearing Research, 2007
- Stability and flexibility of epigenetic gene regulation in mammalian developmentNature, 2007