Prognostic value of olfactory evoked potentials in patients with post-infectious olfactory dysfunction
- 1 March 2021
- journal article
- research article
- Published by Springer Science and Business Media LLC in European Archives of Oto-Rhino-Laryngology
- Vol. 278 (10), 3839-3846
- https://doi.org/10.1007/s00405-021-06683-y
Abstract
Purpose Prognostic assessment of patients with post-infectious olfactory dysfunction (PIOD) poses a challenge for clinicians. While there have been some studies on the prognostic factors of PIOD focusing on demographic factors, the aim of this study was to investigate whether event-related potentials (ERPs) could be used as a new predictor of olfactory recovery in PIOD. Methods This was a retrospective study involving patients who underwent olfactory examinations using Sniffin’ Sticks test before treatment and after 1 year of follow-up. The responder group was defined by an increase of threshold–discrimination–identification (TDI) score of ≥ 6 points. All patients underwent ERP examination and the amplitude and latency of each wave of ERPs were recorded before treatment. Results A total of 61 patients (age 47.50 ± 11.04 years, 27 males) were analyzed. The presence of olfactory ERPs (oERPs) was greater in the responder group than in the non-responder group (P = 0.007), while that of trigeminal ERPs (tERPs) did not differ between the two groups (P = 0.346). Logistic-regression analyses showed that factors associated with improvement of subjective olfactory function were duration (OR, 1.604; 95% CI, 1.062–2.423; P = 0.025), initial threshold (odds ratio [OR], 0.043; 95% confidence interval [CI], 0.004–0.439; P = 0.008), and latency of N1 in oERPs (OR, 1.007; 95% CI, 1.001–1.013; P = 0.021). Conclusion Our study shows that duration of OD, initial threshold, and latency of N1 in oERPs were associated with olfactory improvement in PIOD patients, which may provide guidance for clinicians.Keywords
Funding Information
- Innovative Research Group Project of the National Natural Science Foundation of China (81670903)
- Capital Health Research and Development of Special (2018-2-2065)
This publication has 49 references indexed in Scilit:
- Presence of olfactory event-related potentials predicts recovery in patients with olfactory loss following upper respiratory tract infectionThe Laryngoscope, 2010
- Cognitive factors in odor detection, odor discrimination, and odor identification tasksJournal of Clinical and Experimental Neuropsychology, 2010
- Prognostic Factors of Olfactory DysfunctionJAMA Otolaryngology–Head & Neck Surgery, 2010
- Effects of olfactory training in patients with olfactory lossThe Laryngoscope, 2009
- Predictors of prognosis in patients with olfactory disturbanceAnnals of Neurology, 2008
- Chemosensory event-related potentials in relation to side of stimulation, age, sex, and stimulus concentrationClinical Neurophysiology, 2006
- The clinical significance of electrophysiological measures of olfactory functionBehavioural Brain Research, 2006
- A putative social chemosignal elicits faster cortical responses than perceptually similar odorantsNeuroImage, 2006
- Recovery of Olfactory Function Following Closed Head Injury or Infections of the Upper Respiratory TractJAMA Otolaryngology–Head & Neck Surgery, 2006
- RiechstörungenHNO, 2004