Dynamic responses of the haematopoietic stem cell niche to diverse stresses
- 1 January 2020
- journal article
- review article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 22 (1), 7-17
- https://doi.org/10.1038/s41556-019-0444-9
Abstract
Adult haematopoietic stem cells (HSCs) mainly reside in the bone marrow, where stromal and haematopoietic cells regulate their function. The steady state HSC niche has been extensively studied. In this Review, we focus on how bone marrow microenvironment components respond to different insults including inflammation, malignant haematopoiesis and chemotherapy. We highlight common and unique patterns among multiple cell types and their environment and discuss current limitations in our understanding of this complex and dynamic tissue.Funding Information
- European Hematology Association
- RCUK | Biotechnology and Biological Sciences Research Council (BB/i004033/1)
- Bloodwise (15031 and 15040)
- Cancer Research UK (C36195/A26770, 100045)
- Wellcome Trust (212304/Z/18/Z, 212304/Z/18/Z, 100045)
This publication has 170 references indexed in Scilit:
- Endothelial Jagged-1 Is Necessary for Homeostatic and Regenerative HematopoiesisCell Reports, 2013
- Altered Microenvironmental Regulation of Leukemic and Normal Stem Cells in Chronic Myelogenous LeukemiaCancer Cell, 2012
- Stromal control of cystine metabolism promotes cancer cell survival in chronic lymphocytic leukaemiaNature, 2012
- Bone Marrow Mesenchymal Stem and Progenitor Cells Induce Monocyte Emigration in Response to Circulating Toll-like Receptor LigandsImmunity, 2011
- Calreticulin exposure on malignant blasts predicts a cellular anticancer immune response in patients with acute myeloid leukemiaCell Death & Disease, 2010
- Quiescent haematopoietic stem cells are activated by IFN-γ in response to chronic infectionNature, 2010
- Bone progenitor dysfunction induces myelodysplasia and secondary leukaemiaNature, 2010
- Engraftment and Reconstitution of Hematopoiesis Is Dependent on VEGFR2-Mediated Regeneration of Sinusoidal Endothelial CellsCell Stem Cell, 2009
- Immunosurveillance by Hematopoietic Progenitor Cells Trafficking through Blood, Lymph, and Peripheral TissuesCell, 2007
- Toll-like Receptors on Hematopoietic Progenitor Cells Stimulate Innate Immune System ReplenishmentImmunity, 2006