Objective — To explore the application value of observation of moist wound theory in chronic wound care. Methods — From February 2019 to May 2020, a total of 96 patients with chronic wounds were treated in this hospital. The patients were divided into two groups based on the two-color ball method, with 48 cases in each group. Routine wound nursing (48 patients, the control group) and moist wound theory (48 patients, the experimental group) were used to compare the wound healing between the two groups. Results — The wound healing rate of 48 patients in the experimental group was significantly higher than that in the control group, and there was a significant difference (P