Lung Recruitment, Individualized PEEP, and Prone Position Ventilation for COVID-19-Associated Severe ARDS: A Single Center Observational Study

Abstract

Background: Patients with coronavirus disease 2019 (COVID-19) may develop severe acute respiratory distress syndrome (ARDS). The aim of the study was to explore the lung recruitability, individualized positive end-expiratory pressure (PEEP), and prone position in COVID-19-associated severe ARDS. Methods: Twenty patients who met the inclusion criteria were studied retrospectively (PaO₂/FiO₂ 68.0 ± 10.3 mmHg). The patients were ventilated under volume-controlled mode with tidal volume of 6 mL/kg predicted body weight. The lung recruitability was assessed via the improvement of PaO₂, PaCO₂, and static respiratory system compliance (C_stat) from low to high PEEP (5–15 cmH₂O). Patients were considered recruitable if two out of three parameters improved. Subsequently, PEEP was titrated according to the best C_stat. The patients were turned to prone position for further 18–20 h. Results: For recruitability assessment, average value of PaO₂ was slightly improved at PEEP 15 cmH₂O (68.0 ± 10.3 vs. 69.7 ± 7.9 mmHg, baseline vs. PEEP 15 cmH₂O; p = 0.31). However, both PaCO₂ and C_stat worsened (PaCO₂: 72.5 ± 7.1 vs. 75.1 ± 9.0 mmHg; p < 0.01. C_stat: 17.5 ± 3.5 vs. 16.6 ± 3.9 ml/cmH₂O; p = 0.05). Only four patients (20%) were considered lung recruitable. Individually titrated PEEP was higher than the baseline PEEP (8.0 ± 2.1 cmH₂O vs. 5 cmH₂O, p < 0.001). After 18–20 h of prone positioning, investigated parameters were significantly improved compared to the baseline (PaO₂: 82.4 ± 15.5 mmHg. PaCO₂: 67.2 ± 6.4 mmHg. C_stat: 20.6 ± 4.4 ml/cmH₂O. All p < 0.001 vs. baseline). Conclusions: Lung recruitability was very low in COVID-19-associated severe ARDS. Individually titrated PEEP and prone positioning might improve lung mechanics and blood gasses.