The effects of linalool acupoint application therapy on sleep regulation
Open Access
- 3 February 2021
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in RSC Advances
- Vol. 11 (11), 5896-5902
- https://doi.org/10.1039/d0ra09751a
Abstract
The Shenque acupoint is located in the umbilicus of the human body. In the human body meridians, the Shenque acupoint can regulate body functions. The Shenque acupoint was one of the important acupuncture acupoints for the treatment of insomnia. However, the effect of linalool applied at the Shenque acupoint to improve sleep was unknown. This study explored the hypnotic and sedative effects of the main component of lavender, linalool, on the Shenque acupoint of mice and rats. The effects on the sleep latency and sleep duration were studied with the supra-threshold dose of pentobarbital sodium, and the effects on the sleep rate were studied with the sub-threshold dose of pentobarbital sodium. In order to further study the feasibility and superiority of linalool administered at the Shenque acupoint, a pharmacokinetic study was carried out. The pharmacodynamic results showed that the mice and rats treated with linalool at Shenque had the highest sleep rate, the shortest sleep latency, and the longest sleep duration compared with other groups. The Tmax and t1/2 of the LS were longer than those of the LO, and had the characteristics of sustained release. The relative bioavailability of LS was 323.0 ± 31.66%. This showed that the combination of linalool and the Shenque acupoint had greater medicinal effects. This development will provide a new direction for improving sleep.This publication has 22 references indexed in Scilit:
- Preparation, characterization and pharmacokinetic studies of linalool-loaded nanostructured lipid carriersPharmaceutical Biology, 2016
- The Biological Activities of Cinnamon, Geranium and Lavender Essential OilsMolecules, 2014
- Linalool: a review on a key odorant molecule with valuable biological propertiesFlavour and Fragrance Journal, 2014
- Actions of essential oils on the central nervous system: An updated review.Flavour and Fragrance Journal, 2011
- [Clinical observation on treatment of infantile rotavirus enteritis by umbilical application of lunxieting paste].2010
- Inhaled linalool-induced sedation in micePhytomedicine, 2009
- Mechanism of changes induced in plasma glycerol by scent stimulation with grapefruit and lavender essential oilsNeuroscience Letters, 2007
- [Clinical observation on treatment of senile insomnia with application therapy on Shenque acupoint with gingkgo leaf preparation: a report of 25 cases].2005
- Anti-inflammatory activity of linalool and linalyl acetate constituents of essential oilsPhytomedicine, 2002
- Effects of linalool on glutamatergic system in the rat cerebral cortexNeurochemical Research, 1995