Determination of adequate positive end-expiratory pressure level required for carbon dioxide homeostasis in an animal model of infant laparoscopy
- 1 September 2020
- journal article
- research article
- Published by Wiley in Acta Anaesthesiologica Scandinavica
- Vol. 64 (8), 1114-1119
- https://doi.org/10.1111/aas.13617
Abstract
Background Capnoperitoneum provides a ventilatory challenge due to reduction in end-expiratory lung volume and peritoneal carbon dioxide absorption in both children and adults. The primary aim of this controlled interventional trial was to determine the positive end-expiratory pressure (PEEP) level needed to ensure for adequate carbon dioxide clearance and preservation of carbon dioxide homeostasis in an experimental model of infant laparoscopy. The secondary aim was to evaluate potential effects on cardiac output of PEEP and abdominal pressure level variations in the same setting. Methods Eight chinchilla bastard rabbits were anesthetized and mechanically ventilated. Intra-abdominal pressures were randomly set to 0, 6, and 12 mm Hg by carbon dioxide insufflation. Carbon dioxide clearance using volumetric capnography, arterial blood gas data, and cardiac output was recorded, while PEEP 3, 6, and 9 cmH(2)O were applied in a random order. Results A PEEP of 9 cmH(2)O showed restoration of carbon dioxide clearance without causing changes in arterial partial pressure of carbon dioxide and bicarbonate and with no associated deterioration in cardiac output. Conclusion The results promote a PEEP level of 9 cmH(2)O in this model of infant capnoperitoneum to allow for adequate carbon dioxide removal with subsequent preservation of carbon dioxide homeostasis. The use of high PEEP was not associated with any decrease in cardiac output.Funding Information
- Karolinska Institutet
- Karolinska Institutet
This publication has 17 references indexed in Scilit:
- Changes of diaphragmatic excursion and lung compliance during major laparoscopic pelvic surgery: A prospective observational studyPLOS ONE, 2018
- Laparoscopic Inguinal Hernia Repair in Infants and Children: State-of-the-Art TechniqueEuropean Journal of Pediatric Surgery, 2017
- Safe and optimal pneumoperitoneal pressure for transperitoneal laparoscopic renal surgery in infant less than 10 kg, looked beyond intraoperative period: A prospective randomized studyJournal of Pediatric Urology, 2016
- Lung volume assessments in normal and surfactant depleted lungs: agreement between bedside techniques and CT imagingBMC Anesthesiology, 2014
- Comparison of Static End-expiratory and Effective Lung Volumes for Gas Exchange in Healthy and Surfactant-depleted LungsAnesthesiology, 2013
- Minimising neonatal brain injury: how research in the past five years has changed my clinical practiceArchives of Disease in Childhood, 2007
- Absorption of carbon dioxide during laparoscopy in children measured using a novel mass spectrometric techniqueBritish Journal of Anaesthesia, 2006
- Anaesthetic considerations for laparoscopic surgery in neonates and infants: a practical reviewBest Practice & Research Clinical Anaesthesiology, 2004
- Carbon dioxide elimination during laparoscopy in children is age dependentJournal of Pediatric Surgery, 2003
- Cerebral blood flow in the newborn infant.Archives of Disease in Childhood: Fetal & Neonatal, 1996