Therapeutic mechanisms of mesenchymal stem cells in acute respiratory distress syndrome reveal potentials for Covid-19 treatment
Open Access
- 10 May 2021
- journal article
- review article
- Published by Springer Science and Business Media LLC in Journal of Translational Medicine
- Vol. 19 (1), 1-13
- https://doi.org/10.1186/s12967-021-02862-x
Abstract
The mortality rate of critically ill patients with acute respiratory distress syndrome (ARDS) is 30.9% to 46.1%. The emergence of the coronavirus disease 2019 (Covid-19) has become a global issue with raising dire concerns. Patients with severe Covid-19 may progress toward ARDS. Mesenchymal stem cells (MSCs) can be derived from bone marrow, umbilical cord, adipose tissue and so on. The easy accessibility and low immunogenicity enable MSCs for allogeneic administration, and thus they were widely used in animal and clinical studies. Accumulating evidence suggests that mesenchymal stem cell infusion can ameliorate ARDS. However, the underlying mechanisms of MSCs need to be discussed. Recent studies showed MSCs can modulate immune/inflammatory cells, attenuate endoplasmic reticulum stress, and inhibit pulmonary fibrosis. The paracrine cytokines and exosomes may account for these beneficial effects. In this review, we summarize the therapeutic mechanisms of MSCs in ARDS, analyzed the most recent animal experiments and Covid-19 clinical trial results, discussed the adverse effects and prospects in the recent studies, and highlight the potential roles of MSC therapy for Covid-19 patients with ARDS.Funding Information
- Natural Science Foundation of Hebei Province (C2020405008, H2020405023)
- Scientific Research Project for Higher Education in Hebei Province (ZD2021005)
- National Natural Science Foundation of China (81770492)
- Basic Research Foundation of Hebei North University (JYT2019002, JYT2019006)
This publication has 115 references indexed in Scilit:
- Tissue factor triggers procoagulation in transplanted mesenchymal stem cells leading to thromboembolismBiochemical and Biophysical Research Communications, 2013
- Mesenchymal Stem Cells Repress Th17 Molecular Program through the PD-1 PathwayPLOS ONE, 2012
- Neutrophil Function: From Mechanisms to DiseaseAnnual Review of Immunology, 2012
- Mesenchymal stem cells promote tumor engraftment and metastatic colonization in rat osteosarcoma modelInternational Journal of Oncology, 2011
- Bone Marrow Derived Mesenchymal Stem Cells Inhibit Inflammation and Preserve Vascular Endothelial Integrity in the Lungs after Hemorrhagic ShockPLOS ONE, 2011
- Allogeneic Human Mesenchymal Stem Cells Restore Epithelial Protein Permeability in Cultured Human Alveolar Type II Cells by Secretion of Angiopoietin-1*Online Journal of Public Health Informatics, 2010
- Plasmacytoid Dendritic Cells Control Lung Inflammation and Monocyte Recruitment in Indirect Acute Lung Injury in MiceThe American Journal of Pathology, 2010
- Mesenchymal stem cells induce mature dendritic cells into a novel Jagged-2–dependent regulatory dendritic cell populationBlood, 2009
- Stem Cell Transplantation: The Lung BarrierTransplantation Proceedings, 2007
- The Acute Respiratory Distress SyndromeThe New England Journal of Medicine, 2000