A cerebello-olivary signal for negative prediction error is sufficient to cause extinction of associative motor learning
- 8 November 2020
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature Neuroscience
- Vol. 23 (12), 1550-1554
- https://doi.org/10.1038/s41593-020-00732-1
Abstract
The brain generates negative prediction error (NPE) signals to trigger extinction, a type of inhibitory learning that is responsible for suppressing learned behaviors when they are no longer useful. Neurons encoding NPE have been reported in multiple brain regions. Here, we use an optogenetic approach to demonstrate that GABAergic cerebello-olivary neurons can generate a powerful NPE signal, capable of causing extinction of conditioned motor responses on its own.Keywords
Funding Information
- U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NS103427)
- U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (MH093727, MH114269)
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