Loss of Optineurin Drives Cancer Immune Evasion via Palmitoylation-Dependent IFNGR1 Lysosomal Sorting and Degradation
Open Access
- 24 February 2021
- journal article
- research article
- Published by American Association for Cancer Research (AACR) in Cancer Discovery
- Vol. 11 (7), 1826-1843
- https://doi.org/10.1158/2159-8290.cd-20-1571
Abstract
In colorectal cancer, loss of optineurin led to increased lysosomal degradation of IFNγ receptor 1 (IFNGR1), providing an explanation for the immunotherapy resistance; pharmacologic inhibition of a step in IFNGR1 lysosomal trafficking overcame this effect.Keywords
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Funding Information
- National Cancer Institute National Institutes of Health (R01CA217648, R01CA123088, R01CA099985, R01CA193136, R01CA152470)
- University of Michigan Rogel Cancer Center Grant (CA46592)
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