Noninvasive Prediction of High‐Grade Prostate Cancer via Biparametric MRI Radiomics
- 25 March 2020
- journal article
- research article
- Published by Wiley in Journal of Magnetic Resonance Imaging
- Vol. 52 (4), 1102-1109
- https://doi.org/10.1002/jmri.27132
Abstract
Background Gleason score (GS) is a histologic prognostic factor and the basis of treatment decision‐making for prostate cancer (PCa). Treatment regimens between lower‐grade (GS ≤7) and high‐grade (GS >7) PCa differ largely and have great effects on cancer progression. Purpose To investigate the use of different sequences in biparametric MRI (bpMRI) of the prostate gland for noninvasively distinguishing high‐grade PCa. Study Type Retrospective. Population In all, 489 patients (training cohort: N = 326; test cohort: N = 163) with PCa between June 2008 and January 2018. Field Strength/Sequence 3.0T, pelvic phased‐array coils, bpMRI including T2‐weighted imaging (T2WI) and diffusion‐weighted imaging (DWI); apparent diffusion coefficient map extracted from DWI. Assessment The whole prostate gland was delineated. Radiomic features were extracted and selected using the Kruskal–Wallis test, the minimum redundancy‐maximum relevance, and the sequential backward elimination algorithm. Two single‐sequence radiomic (T2WI, DWI) and two combined (T2WI‐DWI, T2WI‐DWI‐Clinic) models were respectively constructed and validated via logistic regression. Statistical Tests The Kruskal–Wallis test and chi‐squared test were utilized to evaluate the differences among variable groups. P < 0.05 determined statistical significance. The area under the receiver operating characteristic curve (AUC), specificity, sensitivity, and accuracy were used to evaluate model performance. The Delong test was conducted to compare the differences between the AUCs of all models. Result All radiomic models showed significant (P < 0.001) predictive performances. Between the single‐sequence radiomic models, the DWI model achieved the most encouraging results, with AUCs of 0.801 and 0.787 in the training and test cohorts, respectively. For the combined models, the T2WI‐DWI models acquired an AUC of 0.788, which was almost the same with DWI in the test cohort, and no significant difference was found between them (training cohort: P = 0.199; test cohort: P = 0.924). Data Conclusion Radiomics based on bpMRI can noninvasively identify high‐grade PCa before the operation, which is helpful for individualized diagnosis of PCa. Level of Evidence 4 Technical Efficacy Stage 2Keywords
Funding Information
- National Natural Science Foundation of China (81227901, 81271629, 81501616, 81527805, 81671851, 81771924, 81971776, 91959130)
This publication has 37 references indexed in Scilit:
- Prostate Volumes Derived From MRI and Volume-Adjusted Serum Prostate-Specific Antigen: Correlation With Gleason Score of Prostate CancerAmerican Journal of Roentgenology, 2013
- Radiomics: Extracting more information from medical images using advanced feature analysisEuropean Journal of Cancer, 2012
- Automated Computer-derived Prostate Volumes from MR Imaging Data: Comparison with Radiologist-derived MR Imaging and Pathologic Specimen VolumesRadiology, 2012
- Is Apparent Diffusion Coefficient Associated with Clinical Risk Scores for Prostate Cancers that Are Visible on 3-T MR Images?Radiology, 2011
- Significant Discrepancies Between Diagnostic and Pathologic Gleason Sums in Prostate Cancer: The Predictive Role of Age and Prostate-Specific AntigenUrology, 2008
- An Analysis of Radical Prostatectomy in Advanced Stage and High-Grade Prostate CancerEuropean Urology, 2008
- Prostate cancer detection with 3-T MRI: Comparison of diffusion-weighted and T2-weighted imagingEuropean Journal of Radiology, 2007
- Prostate cancer screening: The clinical value of diffusion‐weighted imaging and dynamic MR imaging in combination with T2‐weighted imagingJournal of Magnetic Resonance Imaging, 2006
- The Limited Significance of a Longer Duration of Neoadjuvant Hormonal Therapy prior to Radical Prostatectomy for High-Risk Prostate Cancer in Japanese MenUrologia Internationalis, 2006
- Differentiation of noncancerous tissue and cancer lesions by apparent diffusion coefficient values in transition and peripheral zones of the prostateJournal of Magnetic Resonance Imaging, 2005